ED & Vitality.
Tablets, combos and oral strips for erectile-function research, in the makers' own packs, photographed pack by pack.
Worth reading first
Premature ejaculationVardenafil with dapoxetine: the combination nobody randomised
Dapoxetine has its own premature-ejaculation file and vardenafil has its own erectile-dysfunction file, and the only human study of the two together is a six-volunteer pharmacokinetic one. The combination is sold everywhere and studied almost nowhere — the honest page is about that gap.
Erectile functionSildenafil: the trials in order, and what they actually asked
Twenty-seven randomised trials and 6,659 men, pooled: successful intercourse in 57% of attempts versus 21% on placebo. The 2002 meta-analysis is the most defensible summary of the drug, and the withdrawal arm of a 2000 trial is the most overlooked fact about it.
PharmaSildenafil in diabetes: the erectile endpoint that moved, and the glycaemic one that did not
Two randomised trials, two different questions. In 219 men with type 2 diabetes, sildenafil moved the erection questions of the IIEF from 1.86 and 1.84 to 3.42 and 3.35 out of 5, and held that gain whether HbA1c was above or below 8.3%. In 42 people with prediabetes, sildenafil 25 mg three times daily for 3 months improved the clamp insulin-sensitivity index by 1.84 — with a 95% CI from 0.01 to 3.67 and p = 0.049.